Summary
Stress
- Facilitates drug related behaviours
- Can reverse strain differences in behavioural responses to drugs of abuse
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Glucocorticoids are involved in these effects
Behavioural:
- HR/LR (differ in locomotion response to novelty)
- HR have a higher CORT response to stress
- readily acquire SA of drugs of abuse
- Vertical shift in dose-response curve
- LR
- SA of drugs of abuse can be induced by CORT